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Article

Multiple gene aberrations and breast cancer: lessons from super-responders.

BMC cancer - 29 May 2015

Wheler Jennifer J, Atkins Johnique T, Janku Filip, Moulder Stacy L, Yelensky Roman, Stephens Philip J, Kurzrock Razelle

Abstract excerpt

BACKGROUND: The presence of multiple molecular aberrations in patients with breast cancer may correlate with worse outcomes. CASE PRESENTATIONS: We performed in-depth molecular analysis of patients with estrogen receptor-positive, HER2-negative, hormone therapy-refractory breast cancer, who achieved partial or complete responses when treated with anastrozole and everolimus. Tumors were analyzed using a targeted...

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Identifiers

PMID: 26021831
DOI: 10.1186/s12885-015-1439-y
PMCID: PMC4446801

Genes

FGFR1
CCNE1
IRS2
MCL1
MYC
PRKDC
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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