Article
Novel clusters of highly expressed genes accompany genomic amplification in breast cancers.
FEBS letters - 21 Aug 2007
Ito Emi, Honma Reiko, Yanagisawa Yuka, Imai Jun-ichi, Azuma Sakura, Oyama Tetsunari, Ohwada Susumu, Akiyama Tetsu, Nomura Nobuo, Inoue Jun-ichiro, Watanabe Shinya, Semba Kentaro
Abstract excerpt
Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by...
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