Article

Molecular Epidemiological Study of Germline APC Variant Associated with Hereditary Gastrointestinal Polyposis in Dogs: Current Prevalence in Jack Russell Terriers in Japan and Breed Distribution

2022-04-20

Abstract excerpt

<h4>Background: </h4> Cases of gastrointestinal (GI) neoplastic polyps in Jack Russell Terriers (JRTs) have increased in Japan since the late 2000s. We recently demonstrated that JRTs with GI polyps heterozygously harbor an identical germline variant in the adenomatous polyposis coli ( APC ) gene, c.[462_463delinsTT]; therefore, this is an autosomal dominant hereditary disease. We conducted a molecular epidemiolog...

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Literature Corpus work: 2550cef4-a6ee-5174-bd68-1f0e6b5ca12d
DOI: 10.21203/rs.3.rs-1557638/v1

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