Article
Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jan 2013
Takala-Harrison Shannon, Clark Taane G, Jacob Christopher G, Cummings Michael P, Miotto Olivo, Dondorp Arjen M, Fukuda Mark M, Nosten Francois, Noedl Harald, Imwong Mallika, Bethell Delia, Se Youry, Lon Chanthap, Tyner Stuart D, Saunders David L, Socheat Duong, Ariey Frederic, Phyo Aung Pyae, Starzengruber Peter, Fuehrer Hans-Peter, Swoboda Paul, Stepniewska Kasia, Flegg Jennifer, Arze Cesar, Cerqueira Gustavo C, Silva Joana C, Ricklefs Stacy M, Porcella Stephen F, Stephens Robert M, Adams Matthew, Kenefic Leo J, Campino Susana, Auburn Sarah, MacInnis Bronwyn, Kwiatkowski Dominic P, Su Xin-zhuan, White Nicholas J, Ringwald Pascal, Plowe Christopher V
Abstract excerpt
The recent emergence of artemisinin-resistant Plasmodium falciparum malaria in western Cambodia could threaten prospects for malaria elimination. Identification of the genetic basis of resistance would provide tools for molecular surveillance, aiding efforts to contain resistance. Clinical trials of artesunate efficacy were conducted in Bangladesh, in northwestern Thailand near the Myanmar border, and at two...
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