Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Studying parents and grandparents to assess genetic contributions to early-onset disease.

American journal of human genetics - 1 Feb 2003

Weinberg Clarice R

Abstract excerpt

Suppose DNA is available from affected individuals, their parents, and their grandparents. Particularly for early-onset diseases, maternally mediated genetic effects can play a role, because the mother determines the prenatal environment. The proposed maximum-likelihood approach for the detection of apparent transmission distortion treats the triad consisting of the affected individual and his or her two parents...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Genetic Markers
Share to Likelihood Functions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to Models, Genetic

Share to Parents

Share to Penetrance

Share to Research Design

Source

Open in PubMed Open full text

Identifiers

PMID: 12533786
DOI: 10.1086/346171
PMCID: PMC379235

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Studying parents and grandparents to assess genetic contributions to early-onset disease.PMID 12533786Read ↗

A hybrid design for studying genetic influences on risk of diseases with onset early in life.Semantic proximity Read ↗

Distinguishing the effects of maternal and offspring genes through studies of "case-parent triads".Semantic proximity Read ↗

Case-sibling studies that acknowledge unstudied parents and permit the inclusion of unmatched individuals.Semantic proximity Read ↗

A generalized test of genotype-phenotype causality in population-sampled nuclear families.Semantic proximity Read ↗

Analysis of parent-of-origin effects for secondary phenotypes using case-control mother-child pair data.Semantic proximity Read ↗

Covariate adjusted inference of parent-of-origin effects using case-control mother-child paired multilocus genotype data.Semantic proximity Read ↗

Power calculations for likelihood ratio tests for offspring genotype risks, maternal effects, and parent-of-origin (POO) effects in the presence of missing parental genotypes when unaffected siblings are available.Semantic proximity Read ↗

Joint detection of association, imprinting and maternal effects using all children and their parents.Semantic proximity Read ↗

Nonparametric method for detecting imprinting effect using all members of general pedigrees with missing data.Semantic proximity Read ↗

Disentangling pooled triad genotypes for association studies.Semantic proximity Read ↗

Review of statistical methodologies for the detection of parent-of-origin effects in family trio genome-wide association data with binary disease traits.Semantic proximity Read ↗

A multi-locus likelihood method for assessing parent-of-origin effects using case-control mother-child pairs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.