Article
Is aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men?
International journal of epidemiology - 1 Feb 2013
Au Yeung Shiu Lun, Jiang ChaoQiang, Cheng Kar Keung, Liu Bin, Zhang WeiSen, Lam Tai Hing, Leung Gabriel M, Schooling C Mary
Abstract excerpt
BACKGROUND: Mendelian randomization studies provide a means of assessing causal relations without interventions, but require valid genetic instruments. We assessed the credibility of aldehyde dehydrogenase 2 (ALDH2) as a genetic instrument for alcohol use in Southern Chinese men. METHODS: We genotyped the single nucleotide polymorphism rs671 of ALDH2 in 4867 men from the Guangzhou Biobank Cohort Study. We used...
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