Article
Exploring causal associations of alcohol with cardiovascular and metabolic risk factors in a Chinese population using Mendelian randomization analysis.
Scientific reports - 14 Sept 2015
Taylor Amy E, Lu Feng, Carslake David, Hu Zhibin, Qian Yun, Liu Sijun, Chen Jiaping, Shen Hongbing, Smith George Davey
Abstract excerpt
Observational studies suggest that moderate alcohol consumption may be protective for cardiovascular disease, but results may be biased by confounding and reverse causality. Mendelian randomization, which uses genetic variants as proxies for exposures, can minimise these biases and therefore strengthen causal inference. Using a genetic variant in the ALDH2 gene associated with alcohol consumption, rs671, we...
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