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Article

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

12 Jun 2012

Abstract excerpt

Neoplastic transformation requires the elimination of key tumor suppressors, which may result from E3 ligase-mediated proteasomal degradation. We previously demonstrated a key role for the E3 ubiquitin ligase E6AP in the regulation of promyelocytic leukemia protein (PML) stability and formation of PML nuclear bodies. Here, we report the involvement of the E6AP-PML axis in B-cell lymphoma development. A partial...

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PMID: 22689861
DOI: 10.1182/blood-2011-10-387647

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