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Article

mTORC1 promotes survival through translational control of Mcl-1

29 Jul 2008

Abstract excerpt

Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is a frequent occurrence in human cancers and a major promoter of chemotherapeutic resistance. Inhibition of one downstream target in this pathway, mTORC1, has shown potential to improve chemosensitivity. However, the mechanisms and genetic modifications that confer sensitivity to mTORC1 inhibitors remain unclear. Here, we demonstrate...

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PMID: 18664580
DOI: 10.1073/pnas.0804821105

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