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Article

Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice.

Circulation research - 4 Mar 2011

Rateri Debra L, Moorleghen Jessica J, Balakrishnan Anju, Owens A Phillip, Howatt Deborah A, Subramanian Venkateswaran, Poduri Aruna, Charnigo Richard, Cassis Lisa A, Daugherty Alan

Abstract excerpt

RATIONALE: Human studies and mouse models have provided evidence for angiotensin II (Ang II)-based mechanisms as an underlying cause of aneurysms localized to the ascending aorta. In agreement with this associative evidence, we have published recently that Ang II infusion induces aneurysmal pathology in the ascending aorta. OBJECTIVE: The aim of this study was to define the role of angiotensin II type 1a (AT(1a))...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21252156
DOI: 10.1161/CIRCRESAHA.110.222844
PMCID: PMC3076204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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