Article
Allelic genealogy under overdominant and frequency-dependent selection and polymorphism of major histocompatibility complex loci.
Genetics - 1 Apr 1990
Takahata N, Nei M
Abstract excerpt
To explain the long-term persistence of polymorphic alleles (trans-specific polymorphism) at the major histocompatibility complex (MHC) loci in rodents and primates, a computer simulation study was conducted about the coalescence time of different alleles sampled under various forms of selection. At the same time, average heterozygosity, the number of alleles in a sample, and the rate of codon substitution were...
Topics
- Alleles
- Animals
- Computer Simulation
- Gene Frequency
- Genes, Dominant
- Major Histocompatibility Complex
- Models, Genetic
- Mutation
- Polymorphism, Genetic
- Selection, Genetic