Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathogen resistance and genetic variation at MHC loci.

Evolution; international journal of organic evolution - 1 Oct 2002

Hedrick Philip W

Abstract excerpt

Balancing selection in the form of heterozygote advantage, frequency-dependent selection, or selection that varies in time and/or space, has been proposed to explain the high variation at major histocompatibility complex (MHC) genes. Here the effect of variation of the presence and absence of pathogens over time on genetic variation at multiallelic loci is examined. In the basic model, resistance to each pathogen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Plant Diseases
Share to Heterozygote
Share to Homozygote

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Major Histocompatibility Complex

Share to Models, Genetic

Share to Polymorphism, Genetic

Share to Time Factors

Source

Identifiers

PMID: 12449477
DOI: 10.1111/j.0014-3820.2002.tb00116.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathogen resistance and genetic variation at MHC loci.PMID 12449477Read ↗

How pathogens drive genetic diversity: MHC, mechanisms and misunderstandings.Semantic proximity Read ↗

Red Queen Processes Drive Positive Selection on Major Histocompatibility Complex (MHC) Genes.Semantic proximity Read ↗

Population structure of pathogens: the role of immune selection.Semantic proximity Read ↗

Maintenance of multiallelic polymorphism at the MHC region.Semantic proximity Read ↗

MHC standing genetic variation and pathogen resistance in wild Atlantic salmon.Semantic proximity Read ↗

Parasites and individual major histocompatibility complex diversity--an optimal choice?Semantic proximity Read ↗

Antigenic escape selects for the evolution of higher pathogen transmission and virulence.Semantic proximity Read ↗

Stability of genetic polymorphism in host–parasite interactionsSemantic proximity Read ↗

Pathogen selection drives nonoverlapping associations between HLA lociSemantic proximity Read ↗

Sexual selection and the evolutionary dynamics of the major histocompatibility complex.Semantic proximity Read ↗

Pathogen burden, co-infection and major histocompatibility complex variability in the European badger (Meles meles).Semantic proximity Read ↗

Biological principles of heredity of and resistance to disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.