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Article

Stage-dependent expression of PI3K/Akt-pathway genes in neuroblastoma

12 Dec 2012

Abstract excerpt

The phosphoinositide-3 kinase (PI3K) pathway plays a critical role in cancer cell growth and survival and has also been implicated in the development of the childhood cancer neuroblastoma. In neuroblastoma high mRNA expression of the PI3K catalytic isoform PIK3CD is associated to favorable disease. Yet, activation of Akt is associated with poor prognosis. Since the contribution of the numerous members of this...

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PMID: 23232578
DOI: 10.3892/ijo.2012.1732

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