Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development.

doi:10.1007/s00428-014-1641-3

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Article

Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development.

Virchows Archiv : an international journal of pathology - 1 Oct 2014

El-Habr Elias A, Levidou Georgia, Trigka Eleni-Andriana, Sakalidou Joanna, Piperi Christina, Chatziandreou Ilenia, Spyropoulou Anastasia, Soldatos Rigas, Tomara Georgia, Petraki Kalliopi, Samaras Vassilis, Zisakis Athanasios, Varsos Vassilis, Vrettakos George, Boviatsis Efstathios, Patsouris Efstratios, Saetta Angelica A, Korkolopoulou Penelope

Abstract excerpt

We investigated the significance of PI3K/AKT/mTOR pathway and its interactions with MAPK, JAK/STAT and Notch pathways in meningioma progression. Paraffin-embedded tissue from 108 meningioma patients was analysed for the presence of mutations in PIK3CA and AKT1. These were correlated with the expression status of components of the PI3K/AKT/mTOR pathway, including p85α and p110γ subunits of PI3K, phosphorylated...

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Identifiers

PMID: 25146167
DOI: 10.1007/s00428-014-1641-3

Genes

AKT1
PTEN
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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