Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2

21 Apr 2010

Abstract excerpt

BACKGROUND: Neuroblastoma is a paediatric cancer of the sympathetic nervous system. The single most important genetic indicator of poor clinical outcome is amplification of the MYCN transcription factor. One of many down-stream MYCN targets is miR-184, which is either directly or indirectly repressed by this transcription factor, possibly due to its pro-apoptotic effects when ectopically over-expressed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to MicroRNA in disease regulation
Share to Neuroblastoma Research and Treatments
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20409325
DOI: 10.1186/1476-4598-9-83

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2PMID 20409325Read ↗

Therapeutic targeting of miRNAs in neuroblastomaSemantic proximity Read ↗

PI3King the LockSemantic proximity Read ↗

miR-34a inhibits progression of neuroblastoma by targeting autophagy-related gene 5Semantic proximity Read ↗

MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastomaSemantic proximity Read ↗

Cell Survival Signaling in NeuroblastomaSemantic proximity Read ↗

Network Modeling of microRNA–mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCNSemantic proximity Read ↗

MicroRNA Involvement in the Pathogenesis of Neuroblastoma: Potential for MicroRNA Mediated TherapeuticsSemantic proximity Read ↗

p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic SignificanceSemantic proximity Read ↗

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastomaSemantic proximity Read ↗

MiR‐181a/b induce the growth, invasion, and metastasis of neuroblastoma cells through targeting ABI1Semantic proximity Read ↗

Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumorsSemantic proximity Read ↗

Silencing of MYCN by RNA interference induces growth inhibition, apoptotic activity and cell differentiation in a neuroblastoma cell line with MYCN amplificationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.