Article
Medulloblastomics: the end of the beginning.
Nature reviews. Cancer - 1 Dec 2012
Northcott Paul A, Jones David T W, Kool Marcel, Robinson Giles W, Gilbertson Richard J, Cho Yoon-Jae, Pomeroy Scott L, Korshunov Andrey, Lichter Peter, Taylor Michael D, Pfister Stefan M
Abstract excerpt
The division of medulloblastoma into different subgroups by microarray expression profiling has dramatically changed our perspective of this malignant childhood brain tumour. Now, the availability of next-generation sequencing and complementary high-density genomic technologies has unmasked novel driver mutations in each medulloblastoma subgroup. The implications of these findings for the management of patients...
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