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Article

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2015

Carta Sonia, Penco Federica, Lavieri Rosa, Martini Alberto, Dinarello Charles Anthony, Gattorno Marco, Rubartelli Anna

Abstract excerpt

Cell stress is implicated in triggering bouts of systemic inflammation in patients with autoinflammatory disorders. Blood monocytes from patients affected by NLRP3-mediated cryopyrin-associated periodic syndromes (CAPS) release greater amounts of IL-1β than monocytes from unaffected subjects. Her...

Read the complete abstract on PubMed

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Share to Adenosine Triphosphate
Share to Cryopyrin-Associated Periodic Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammasomes

Share to Monocytes

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Oxidation-Reduction

Share to Receptors, Purinergic P2X7

Share to Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 25730877
DOI: 10.1073/pnas.1424741112
PMCID: PMC4352822

Genes

CAPS
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25730877-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance.PMID 25730877Read ↗

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