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Article

N-Acetyltransferase 2 Genotypes among Zulu-Speaking South Africans and Isoniazid and N-Acetyl-Isoniazid Pharmacokinetics during Antituberculosis Treatment.

Antimicrobial agents and chemotherapy - 24 Mar 2020

Mthiyane Thuli, Millard James, Adamson John, Balakrishna Yusentha, Connolly Cathy, Owen Andrew, Rustomjee Roxana, Dheda Keertan, McIlleron Helen, Pym Alexander S

Abstract excerpt

The distribution of N-acetyltransferase 2 gene (NAT2) polymorphisms varies considerably among different ethnic groups. Information on NAT2 single-nucleotide polymorphisms in the South African population is limited. We investigated NAT2 polymorphisms and their effect on isoniazid pharmacokinetics (PK) in Zulu black HIV-infected South Africans in Durban, South Africa. HIV-infected participants with...

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Identifiers

PMID: 31964788
DOI: 10.1128/AAC.02376-19
PMCID: PMC7179278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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