Article
Unscheduled DNA synthesis and HPRT mutation in fetal Syrian hamster and human respiratory epithelial cells exposed to ethylnitrosourea.
Cancer letters - 9 Apr 1990
Wen J, Emura M, Riebe M, Mohr U
Abstract excerpt
We previously reported that the chromosomes of fetal Syrian hamster respiratory epithelial cells were less stable toward ethylnitrosourea (ENU) than those of comparable human cells. Following this, we compared the sensitivity of genetic materials of the same cell systems to the same mutagen in terms of unscheduled DNA synthesis (UDS) and mutation at HPRT locus (HPRT-). UDS occurred 5 (with 0.1 mg ENU/ml) to 7...
Topics
- Animals
- Bronchi
- Cricetinae
- DNA Repair
- Ethylnitrosourea
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Lung
- Mesocricetus
- Mutation
- Species Specificity