Urethane and N-nitrosodiethylamine are mutagenic for the Syrian hamster fetus.

doi:10.1016/j.mrgentox.2008.07.011

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Article

Urethane and N-nitrosodiethylamine are mutagenic for the Syrian hamster fetus.

Mutation research - 8 Dec 2008

Donovan Paul J, Smith George T

Abstract excerpt

Urethane and N-nitrosodiethylamine are soluble environmental carcinogens that initiate tumors transplacentally, but have a mixed history of effectiveness in mutagenesis assays in vitro or in vivo with adult rodents. To test for their transplacental mutagenicity, Syrian hamster fetuses at 12 days in gestation were exposed transplacentally to urethane or N-nitrosodiethylamine at 0.5 or 1.0 mM/kg. The fetal cells...

Topics

Alkylating Agents
Animals
Carcinogens
Cricetinae
Diethylnitrosamine
Female
Fetus
Mutagens
Mutation
Pregnancy
Urethane

Source

Open in PubMed

Identifiers

PMID: 18755288
DOI: 10.1016/j.mrgentox.2008.07.011

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