Article
FOXP3 -3279 and IVS9+459 polymorphisms are associated with genetic susceptibility to myasthenia gravis.
Neuroscience letters - 8 Feb 2013
Zhang Junmei, Chen Yuqian, Jia Ge, Chen Xiaoli, Lu Jiayin, Yang Huan, Zhou Wenbin, Xiao Bo, Zhang Ning, Li Jing
Abstract excerpt
Myasthenia gravis (MG) is an autoimmune disorder in which CD4(+)CD25(+) FOXP3(+)regulatory T cells (Tregs) are thought to play important roles in driving the ongoing autoimmune response. Although it is known that single-nucleotide polymorphisms (SNPs) in the fork head/winged-helix transcription factor 3 (FOXP3) gene contribute to some autoimmune diseases, information about the role of this gene in MG is limited....
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