Identification of rs28362336 as a risk SNP for generalized myasthenia gravis and its impact on HCG27 regulation.

doi:10.1371/journal.pone.0359069

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Article

Identification of rs28362336 as a risk SNP for generalized myasthenia gravis and its impact on HCG27 regulation.

PloS one - 1 Jan 2026

Chen Zihong, Guo Qingling, Tian Liting, Jin Jingnan, Wang Xia, Yu Chunyu, Li Yichen, Zhang Jingjing, Li Yan, Zhao Yufan, Zhang Jiayi, Zhang Lanxin, Qiao Lukuan, Wang Jianjian

Abstract excerpt

Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junctions. Accumulating amounts of evidence have indicated that single nucleotide polymorphisms (SNPs) and long noncoding RNAs (lncRNAs) play critical roles in the pathogenesis of MG; however, research on MG-related lncRNA SNPs remains limited. Therefore, our study focused on MG-related lncRNA SNPs to explore their association...

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Topics

Humans
Polymorphism, Single Nucleotide
Female
Myasthenia Gravis
RNA, Long Noncoding
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Case-Control Studies

Adult

Middle Aged

Genome-Wide Association Study

Risk Factors

Quantitative Trait Loci

Genotype

Gene Frequency

Source

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Identifiers

PMID: 42776983
DOI: 10.1371/journal.pone.0359069
PMCID: PMC13600526

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