Article
HLA-G may predict the disease course in patients with early rheumatoid arthritis.
Human immunology - 1 Apr 2013
Rizzo Roberta, Farina Ilaria, Bortolotti Daria, Galuppi Elisa, Rotola Antonella, Melchiorri Loredana, Ciancio Giovanni, Di Luca Dario, Govoni Marcello
Abstract excerpt
The current management of early rheumatoid arthritis (ERA) is to start an intensive treatment as soon as possible. To avoid under/overtreatment, it is important to identify reliable ERA evolution biomarkers. HLA-G molecules has been associated with rheumatoid arthritis, suggesting a role in disease regulation. HLA-G antigens are expressed as membrane bound and soluble isoforms (mHLA-G, sHLA-G) that act as ligand...
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