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Article

Establishment of a medium-throughput approach for the genotyping of RHD variants and report of nine novel rare alleles.

Transfusion - 1 Aug 2013

Fichou Yann, Le Maréchal Cédric, Jamet Déborah, Bryckaert Laurence, Ka Chandran, Audrézet Marie-Pierre, Le Gac Gérald, Dupont Isabelle, Chen Jian-Min, Férec Claude

Abstract excerpt

BACKGROUND: The routinely used serologic methods are robust in accurately typing standard D- or D+ blood. However, they result in discrepancy in weak or partial D blood, which requires genetic analysis. We have previously used denaturing high-performance liquid chromatography (DHPLC) to screen the entire RHD-coding sequence. However, DHPLC is technically challenging, labor-intensive, and time-consuming. To...

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PMID: 23228153
DOI: 10.1111/trf.12009

Genes

RHD

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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