Article
Variant screening of the RHD gene in a large cohort of subjects with D phenotype ambiguity: report of 17 novel rare alleles.
Transfusion - 1 Apr 2012
Fichou Yann, Le Maréchal Cédric, Bryckaert Laurence, Guerry Christine, Bénech Caroline, Dupont Isabelle, Jamet Déborah, Férec Claude, Chen Jian-Min
Abstract excerpt
BACKGROUND: A considerable number of RHD alleles responsible for weak and partial D phenotypes have been identified over the past decade. Two particular concerns, namely, 1) that red blood cells of these phenotypes may cause anti-D immunization when transfused to D- recipients and 2) that serologic determination of these phenotypes is often doubtful, make genetic analysis of the RHD gene highly desirable. STUDY...
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