Article
Weak D phenotypes caused by intronic mutations in the RHD gene: four novel weak D alleles identified in the Chinese population.
Transfusion - 1 Aug 2013
Ye Luyi, He Yunlei, Gao Huanhuan, Guo Zhonghui, Zhu Ziyan
Abstract excerpt
BACKGROUND: Although more than 80 weak D types have been reported, many rare alleles probably remain unidentified. However, direct evidence that associates intronic mutations in the RHD gene with weak D types is lacking. STUDY DESIGN AND METHODS: Blood samples were obtained from Shanghai Blood Center. D- samples typed in routine laboratories were tested using a monoclonal immunoglobulin M reagent, an indirect...
Topics
- Alleles
- Base Sequence
- China
- Computational Biology
- Genetic Markers
- Genotype
- Genotyping Techniques
- Humans
- Introns
- Molecular Sequence Data
- Mutation
- Phenotype
- RNA Splice Sites
- Rh-Hr Blood-Group System
- Sequence Analysis, DNA