Article
Molecular and computational analysis of 45 samples with a serologic weak D phenotype detected among 132,479 blood donors in northeast China.
Journal of translational medicine - 27 Nov 2019
Zhang Xu, Li Guiji, Zhou Zhuren, Shao Chaopeng, Huang Xuying, Li Lichun, Li Xiaofeng, Liu Ying, Fan Hua, Li Jianping
Abstract excerpt
BACKGROUND: RH1 is one of the most clinically important blood group antigens in the field of transfusion and in the prevention of fetal incompatibility. The molecular analysis and characterization of serologic weak D phenotypes is essential to ensuring transfusion safety. METHODS: Blood samples from a northeastern Chinese population were randomly screened for a serologic weak D phenotype. The nucleotide sequences...
Topics
- Alleles
- Amino Acid Substitution
- Blood Donors
- China
- Computational Biology
- Gene Frequency
- Humans
- Mutant Proteins
- Phenotype
- Protein Structure, Tertiary
- Rh-Hr Blood-Group System
- Serologic Tests