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Article

Raf Kinase Inhibitor Protein Expression in a Survival Analysis of Colorectal Cancer Patients

18 Dec 2006

Abstract excerpt

PURPOSE: Raf kinase inhibitor protein (RKIP) inhibits the Raf and nuclear factor kappa B signaling pathways, and suppresses metastasis in animal models. We examined whether RKIP expression in primary colorectal cancers (CRCs) correlates with the risk of metastasis and overall survival. PATIENTS AND METHODS: RKIP expression was examined immunohistochemically in three separate cohorts: a tissue microarray...

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Identifiers

PMID: 17179102
DOI: 10.1200/jco.2006.07.5499

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