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Article

KRAS and PIK3CA mutations in colorectal adenocarcinomas correlate with aggressive histological features and behavior.

Human pathology - 1 Jul 2017

Jang Sejin, Hong Mineui, Shin Mi Kyung, Kim Byung Chun, Shin Hyung-Sik, Yu Eunsil, Hong Seung-Mo, Kim Jihun, Chun Sung-Min, Kim Tae-Im, Choi Kyung-Chan, Ko Young Woong, Kim Jeong Won

Abstract excerpt

Tumor budding (TB) in colorectal carcinoma (CRC) is related to epithelial-mesenchymal transition and has been recently characterized as an indicator of poor prognosis along with lymphovascular tumor emboli, perineural invasion, and an infiltrative growth pattern. Mutations in the genes of the Ras-mitogen-activated protein kinase and phosphatidylinositol-4,5-bisphosphate 3-kinase pathways are associated with...

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Identifiers

PMID: 28188750
DOI: 10.1016/j.humpath.2017.01.010

Genes

KRAS
BRAF
NRAS
POLE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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