Article
Imputation of coding variants in African Americans: better performance using data from the exome sequencing project.
Bioinformatics (Oxford, England) - 1 Nov 2013
Duan Qing, Liu Eric Yi, Auer Paul L, Zhang Guosheng, Lange Ethan M, Jun Goo, Bizon Chris, Jiao Shuo, Buyske Steven, Franceschini Nora, Carlson Chris S, Hsu Li, Reiner Alex P, Peters Ulrike, Haessler Jeffrey, Curtis Keith, Wassel Christina L, Robinson Jennifer G, Martin Lisa W, Haiman Christopher A, Le Marchand Loic, Matise Tara C, Hindorff Lucia A, Crawford Dana C, Assimes Themistocles L, Kang Hyun Min, Heiss Gerardo, Jackson Rebecca D, Kooperberg Charles, Wilson James G, Abecasis Gonçalo R, North Kari E, Nickerson Deborah A, Lange Leslie A, Li Yun
Abstract excerpt
SUMMARY: Although the 1000 Genomes haplotypes are the most commonly used reference panel for imputation, medical sequencing projects are generating large alternate sets of sequenced samples. Imputation in African Americans using 3384 haplotypes from the Exome Sequencing Project, compared with 2184 haplotypes from 1000 Genomes Project, increased effective sample size by 8.3-11.4% for coding variants with minor...
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