Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRIg mediates early Kupffer cell responses to adenovirus

6 Dec 2012

Abstract excerpt

Whereas adenoviral vectors are known to activate the complement cascade, leading to fixation of C3 proteins to the viral capsid, the consequences of this activation for viral clearance from the circulation are not known. Liver KCs, the macrophage population responsible for early uptake and elimination of many blood-borne pathogens, express CRIg, a complement receptor for C3 proteins. Here, we find that CRIg is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Viral Infections and Outbreaks Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23225913
DOI: 10.1189/jlb.0612311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRIg mediates early Kupffer cell responses to adenovirusPMID 23225913Read ↗

CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complementSemantic proximity Read ↗

Complement C4 Prevents Viral Infection through Capsid InactivationSemantic proximity Read ↗

Liver Monocytes and Kupffer Cells Remain Transcriptionally Distinct during Chronic Viral Infection.Semantic proximity Read ↗

Coxsackievirus B3 Activates Macrophages Independently of CAR-Mediated Viral EntrySemantic proximity Read ↗

Adenovirus activates complement by distinctly different mechanisms in vitro and in vivo: indirect complement activation by virions in vivo.Semantic proximity Read ↗

Structure of C3b in complex with CRIg gives insights into regulation of complement activation.Semantic proximity Read ↗

Phenotypic and functional profiles of CRIg (Z39Ig)-expressing macrophages in the large intestine.Semantic proximity Read ↗

Adenovirus phagocytosis by neutrophils triggers a pro-inflammatory responseSemantic proximity Read ↗

Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver.Semantic proximity Read ↗

3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAVSemantic proximity Read ↗

Kinetics of local C3 production orchestrates neutrophil recruitment in lung injurySemantic proximity Read ↗

Analysis of Adenovirus Sequestration in the Liver, Transduction of Hepatic Cells, and Innate Toxicity after Injection of Fiber-Modified VectorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.