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Article

Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis.

Development (Cambridge, England) - 1 Dec 2003

Huang Chengqun, Sheikh Farah, Hollander Melinda, Cai Chengleng, Becker David, Chu Po-Hsien, Evans Sylvia, Chen Ju

Abstract excerpt

The requirement for atrial function in developing heart is unknown. To address this question, we have generated mice deficient in atrial myosin light chain 2 (MLC2a), a major structural component of the atrial myofibrillar apparatus. Inactivation of the Mlc2a gene resulted in severely diminished atrial contraction and consequent embryonic lethality at ED10.5-11.5, demonstrating that atrial function is essential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14573518
DOI: 10.1242/dev.00831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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