RpoB8, a rifampicin-resistant termination-proficient RNA polymerase, has an increased Km for purine nucleotides during transcription elongation.

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Article

RpoB8, a rifampicin-resistant termination-proficient RNA polymerase, has an increased Km for purine nucleotides during transcription elongation.

The Journal of biological chemistry - 5 Aug 1991

Jin D J, Gross C A

Abstract excerpt

The rpoB8 allele of Escherichia coli maps to the beta-subunit of RNA polymerase and confers rifampicin resistance as well as increased termination at both intrinsic and rho-dependent terminators in vivo. This phenotype suggests that the mutant is defective in an enzymatic property of RNA polymera...

Topics

Alleles
DNA, Bacterial
DNA-Directed RNA Polymerases
Drug Resistance
Electrophoresis, Polyacrylamide Gel
Escherichia coli
Kinetics
Mutation
Promoter Regions, Genetic
Purine Nucleotides
Rifampin
Templates, Genetic
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 1860856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1860856-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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