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Article

In vivo enhanced expression of patched dampens the sonic hedgehog pathway.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2002

Bergstein Ivan, Leopold Philip L, Sato Noboru, Panteleyev Andrei, Christiano Angela, Crystal Ronald

Abstract excerpt

The sonic hedgehog (SHH)-patched (PTCH) pathway functions in normal embryonic development of the brain, musculoskeletal system, and hair follicles, and in normal post-natal control of hair follicles. Dysregulation of the pathway has been implicated in a variety of neoplasias, including those of skin and brain. Based on the knowledge that generalized, prolonged PTCH expression can inhibit the effects of SHH...

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Source

Identifiers

PMID: 12161193
DOI: 10.1006/mthe.2002.0628

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vivo enhanced expression of patched dampens the sonic hedgehog pathway.PMID 12161193Read ↗

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