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Cell Plasticity and Heterogeneity in Cancer

7 Dec 2012

Abstract excerpt

BACKGROUND: Heterogeneity within a given cancer arises from diverse cell types recruited to the tumor and from genetic and/or epigenetic differences amongst the cancer cells themselves. These factors conspire to create a disease with various phenotypes. There are 2 established models of cancer development and progression to metastatic disease. These are the clonal evolution and cancer stem cell models. CONTENT:...

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PMID: 23220226
DOI: 10.1373/clinchem.2012.184655

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