Interleukin-28B rs12979860 C allele: Protective against  advanced fibrosis in chronic hepatitis C genotype  1 infection.

doi:10.1111/jgh.12544

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Article

Interleukin-28B rs12979860 C allele: Protective against advanced fibrosis in chronic hepatitis C genotype 1 infection.

Journal of gastroenterology and hepatology - 1 Jan 2014

Kitson Matthew T, George Jacob, Dore Gregory J, Leung Reynold, Button Peter, McCaughan Geoffrey W, Grawford Darrell H G, Siebert William, Weltman Martin D, Cheng Wendy S C, Roberts Stuart K

Abstract excerpt

Background and Aim: While genetic polymorphisms upstream of the interleukin-28B(IL28B) gene are associated with necroinflammatory activity grade in chronic hepatitis C virus genotype 1 (HCV-1) infection, any association with fibrosis is less definitive. Pretreatment liver biopsies in a cohort of treatment-naïve patients with HCV-1 were analyzed to evaluate associations between liver histology, and the rs12979860...

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PMID: 25587616
DOI: 10.1111/jgh.12544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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