Article
IL28B SNP rs12979860 is a critical predictor for on-treatment and sustained virologic response in patients with hepatitis C virus genotype-1 infection.
PloS one - 30 Mar 2011
Lin Chun-Yen, Chen Ji-Yih, Lin Tsung-Nan, Jeng Wen-Juei, Huang Chien-Hao, Huang Chang-Wen, Chang Su-Wei, Sheen I-Shyan
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) of interleukin-28B (IL28B) have received considerable interest for their association with sustained virological response (SVR) when treating patients of genotype-1 hepatitis C virus (GT1-HCV) chronic infection with pegylated interferon and ribavirin (PegIFN/RBV). This study was to investigate the predictive power of IL28B SNPs for on-treatment responses and SVR...
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