Article
Tacrolimus and Diabetes in Kidney Transplantation: The Impact of Cyp3a5 Gene Polymorphism.
Transplantation proceedings - 1 Dec 2023
Liang Siyu, Zhu Xiaoqiu, Cai Ruiming, Yan Baomei, Liang Weixiang, Cai Mingjin, Yang Pengfeng
Abstract excerpt
BACKGROUND: To explore the correlation between single nucleotide polymorphisms (SNPs) of CYP3A4 rs2740574 and CYP3A5 rs776746 and post-transplant diabetes mellitus (PTDM) in Chinese renal allograft recipients treated with tacrolimus. METHODS: A total of 244 patients treated with tacrolimus were included in this study, wherein DNA sequencing was detected through fluorescence in situ hybridization, and SNP...
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