Article
Know thy neighbor: stromal cells can contribute oncogenic signals.
Current opinion in genetics & development - 1 Feb 2001
Tlsty T D, Hein P W
Abstract excerpt
Although the stroma within carcinogenic lesions is known to be supportive and responsive to tumors, new data increasingly show that the stroma also has a more active, oncogenic role in tumorigenesis. Stromal cells and their products can transform adjacent tissues in the absence of pre-existing tumor cells by inciting phenotypic and genomic changes in the epithelial cells. The oncogenic action of distinctive...
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