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Article

Stromagenesis: the changing face of fibroblastic microenvironments during tumor progression.

Seminars in cancer biology - 1 Oct 2005

Beacham Dorothy A, Cukierman Edna

Abstract excerpt

During tumorigenesis, reciprocal changes in stromal fibroblasts and tumor cells induce changes to the neoplastic microenvironmental landscape. In stromagenesis, both the complex network of bi-directional stromal fibroblastic signaling pathways and the stromal extracellular matrix are modified. The presence of a 'primed' stroma during the early, reversible stage of tumorigenesis is optimal for stromal-directed...

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PMID: 15970443
DOI: 10.1016/j.semcancer.2005.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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