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Mitochondria, Cognitive Impairment, and Alzheimer's Disease

1 Jan 2009

Abstract excerpt

To date, the beta amyloid (Abeta) cascade hypothesis remains the main pathogenetic model of Alzheimer's disease (AD), but its role in the majority of sporadic AD cases is unclear. The "mitochondrial cascade hypothesis" could explain many of the biochemical, genetic, and pathological features of sporadic AD. Somatic mutations in mitochondrial DNA (mtDNA) could cause energy failure, increased oxidative stress, and...

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PMID: 20798880
DOI: 10.4061/2009/951548

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