Article
A cancer-specific variant of the SLCO1B3 gene encodes a novel human organic anion transporting polypeptide 1B3 (OATP1B3) localized mainly in the cytoplasm of colon and pancreatic cancer cells.
Molecular pharmaceutics - 7 Jan 2013
Thakkar Nilay, Kim Kyungbo, Jang Eun Ryoung, Han Songhee, Kim Kyunghwa, Kim Donghern, Merchant Nipun, Lockhart A Craig, Lee Wooin
Abstract excerpt
OATP1B3 is a member of the OATP (organic anion transporting polypeptides) superfamily, responsible for mediating the transport of numerous endogenous and xenobiotic substances. Although initially reported to be exclusively expressed in the liver, several studies reported that OATP1B3 is frequently expressed in multiple types of cancers and may be associated with differing clinical outcomes. However, a detailed...
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