Article
ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells.
The Journal of biological chemistry - 11 Jan 2013
Tsuruoka Nobuhide, Arima Masafumi, Yoshida Nobuya, Okada Seiji, Sakamoto Akemi, Hatano Masahiko, Satake Hisae, Arguni Eggi, Wang Ji-Yang, Yang Jing-Hua, Nishikura Kazuko, Sekiya Souei, Shozu Makio, Tokuhisa Takeshi
Abstract excerpt
Somatic mutations accumulate in senescent cells. Bcl6, which functions as a transcriptional repressor, has been identified as a potent inhibitor of cell senescence, but a role of Bcl6 in the accumulation of somatic mutations has remained unclear. Ig class-switch recombination simultaneously induces somatic mutations in an IgM class-switch (Ig-Sμ) region of IgG B cells. Surprisingly, mutations were detected in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.