Article
The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres.
Genes & development - 1 Dec 2012
Chambers Anna L, Ormerod Georgina, Durley Samuel C, Sing Tina L, Brown Grant W, Kent Nicholas A, Downs Jessica A
Abstract excerpt
The INO80 chromatin remodeling complex functions in transcriptional regulation, DNA repair, and replication. Here we uncover a novel role for INO80 in regulating chromosome segregation. First, we show that the conserved Ies6 subunit is critical for INO80 function in vivo. Strikingly, we found that loss of either Ies6 or the Ino80 catalytic subunit results in rapid increase in ploidy. One route to polyploidy is...
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