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Article

Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research.

Biomolecules - 2 Feb 2024

Bin Yixiao, Wei Sanhua, Chen Ruo, Zhang Haowei, Ren Jing, Liu Peijuan, Xin Zhiqian, Zhang Tianjiao, Yang Haijiao, Wang Ke, Feng Zhuan, Sun Xiuxuan, Chen Zhinan, Zhang Hai

Abstract excerpt

Severe combined immunodeficient (SCID) mice serve as a critical model for human xenotransplantation studies, yet they often suffer from low engraftment rates and susceptibility to graft-versus-host disease (GVHD). Moreover, certain SCID strains demonstrate 'immune leakage', underscoring the need for novel model development. Here, we introduce an SCID mouse model with a targeted disruption of the dclre1c gene,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38397417
DOI: 10.3390/biom14020180
PMCID: PMC10887050

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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