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Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis

6 Feb 2012

Abstract excerpt

Cernunnos is involved in the nonhomologous end-joining (NHEJ) process during DNA double-strand break (DSB) repair. Here, we studied immunoglobulin (Ig) class switch recombination (CSR), a physiological process which relies on proper repair of the DSBs, in B cells from Cernunnos-deficient patients. The pattern of in vivo generated CSR junctions is altered in these cells, with unusually long microhomologies and a...

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PMID: 22312109
DOI: 10.1084/jem.20110325

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