Article
The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2+ release.
The Journal of biological chemistry - 18 Jan 2013
Wang Xu, Xiong Liang Wen, El Ayadi Amina, Boehning Darren, Putkey John A
Abstract excerpt
PEP-19 is a small, intrinsically disordered protein that binds to the C-domain of calmodulin (CaM) via an IQ motif and tunes its Ca(2+) binding properties via an acidic sequence. We show here that the acidic sequence of PEP-19 has intrinsic Ca(2+) binding activity, which may modulate Ca(2+) binding to CaM by stabilizing an initial Ca(2+)-CaM complex or by electrostatically steering Ca(2+) to and from CaM. Because...
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