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Article

Biomechanical modeling and morphology analysis indicates plaque rupture due to mechanical failure unlikely in atherosclerosis-prone mice.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2013

Campbell Ian C, Weiss Daiana, Suever Jonathan D, Virmani Renu, Veneziani Alessandro, Vito Raymond P, Oshinski John N, Taylor W Robert

Abstract excerpt

Spontaneous plaque rupture in mouse models of atherosclerosis is controversial, although numerous studies have discussed so-called "vulnerable plaque" phenotypes in mice. We compared the morphology and biomechanics of two acute and one chronic murine model of atherosclerosis to human coronaries of the thin-cap fibroatheroma (TCFA) phenotype. Our acute models were apolipoprotein E-deficient (ApoE(-/-)) and LDL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23203971
DOI: 10.1152/ajpheart.00620.2012
PMCID: PMC3774501

Genes

ANG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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