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Article

Thin-capped atheromata with reduced collagen content in pigs develop in coronary arterial regions exposed to persistently low endothelial shear stress.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2013

Koskinas Konstantinos C, Sukhova Galina K, Baker Aaron B, Papafaklis Michail I, Chatzizisis Yiannis S, Coskun Ahmet U, Quillard Thibaut, Jonas Michael, Maynard Charles, Antoniadis Antonios P, Shi Guo-Ping, Libby Peter, Edelman Elazer R, Feldman Charles L, Stone Peter H

Abstract excerpt

OBJECTIVE: The mechanisms promoting the focal formation of rupture-prone coronary plaques in vivo remain incompletely understood. This study tested the hypothesis that coronary regions exposed to low endothelial shear stress (ESS) favor subsequent development of collagen-poor, thin-capped plaques...

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Identifiers

PMID: 23640495
DOI: 10.1161/ATVBAHA.112.300827
PMCID: PMC3954496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23640495-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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