Article
FcγRIIb on myeloid cells and intrinsic renal cells rather than B cells protects from nephrotoxic nephritis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2013
Sharp Phoebe E H, Martin-Ramirez Javier, Mangsbo Sara M, Boross Peter, Pusey Charles D, Touw Ivo P, Cook H Terence, Verbeek J Sjef, Tarzi Ruth M
Abstract excerpt
FcγRIIb is the sole inhibitory FcR for IgG in humans and mice, where it is involved in the negative regulation of Ab production and cellular activation. FcγRIIb-deficient mice show exacerbated disease following the induction of nephrotoxic nephritis (NTN). In this study, we determined the cellular origin of the FcγRIIb-knockout phenotype by inducing NTN in mice with a deficiency of FcγRIIb on either B cells alone...
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